LYSOSOMAL DYSFUNCTION IN DIABETIC CARDIOMYOPATHY

Lysosomal dysfunction in diabetic cardiomyopathy

Diabetes is a major risk factor for a variety of cardiovascular complications, while diabetic cardiomyopathy, a disease specific to the myocardium independent of vascular lesions, is an important causative factor for increased risk of heart failure and mortality in diabetic populations.Lysosomes have long been recognized as intracellular trash bags

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Double-Stranded DNA in Exosomes of Malignant Pleural Effusions as a Novel DNA Source for EGFR Mutation Detection in Lung Adenocarcinoma

Background: Exosomes are cell-derived vesicles and bear a specific set of nucleic acids including DNA (exoDNA).Thus, this study is to explore whether exoDNA in malignant pleural effusions (MPEs) could be a novel DNA source for mutation detection of Apparel epidermal growth factor receptor (EGFR).Methods: In this study, 52 lung adenocarcinoma patien

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